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● Why China Leads in Procaine HCl Supply
● 1. TNJ Chemical (Nanjing, Jiangsu)
● 2. Hebei Guanlang Biotechnology (Shijiazhuang, Hebei)
● 3. Zhengzhou Yibang Industry & Trade (Henan)
● 4. Hubei Aoks Bio-Tech (Wuhan, Hubei)
● 5. Wuhan Monad Pharmaceutical Technology (Hubei)
● 6. Xi'an Tian Guangyuan Biotech (Shaanxi)
● 7. Zhejiang Bamboo Pharmaceuticals (Zhejiang)
● 8. Chongqing Southwest No.2 Pharmaceutical Factory (Chongqing)
● 9. Remedy Labs (Various Locations)
● 10. SupplyBenzocaine.co.uk (Multi-Site Factory, China)
● Manufacturing Processes in China
● Quality Assurance and Certifications
● Market Trends and Applications
● FAQ
>> 1. What is Procaine HCl primarily used for?
>> 2. How do I verify a supplier's quality and compliance?
>> 3. What are standard lead times and shipping options from China?
>> 4. Does SupplyBenzocaine.co.uk offer OEM and customization?
>> 5. What payment terms and MOQs are typical?
China has emerged as a global powerhouse in the production and supply of Procaine HCl, a critical local anesthetic widely used in medical, dental, and pharmaceutical applications. With its vast manufacturing capabilities, stringent quality standards, and competitive pricing, the country dominates the market, serving international brands, wholesalers, and producers seeking reliable OEM services. This comprehensive guide ranks the top 10 Procaine HCl suppliers in China, detailing their strengths, production processes, certifications, and unique offerings to help you make informed sourcing decisions.
Procaine HCl, also known as Novocain, is a synthetic ester-type local anesthetic with the chemical formula C13H20N2O2·HCl (CAS 51-05-8). Developed in the early 1900s by German chemists Alfred Einhorn and Heinrich Dreser, it was one of the first injectable anesthetics to replace cocaine due to its lower toxicity and addiction potential. Procaine works by blocking voltage-gated sodium channels in nerve membranes, thereby inhibiting the propagation of action potentials and providing temporary numbness in targeted areas.
Its primary applications include dental procedures like root canals and extractions, minor surgical interventions, infiltrative anesthesia, and even veterinary medicine for pain management in animals. Procaine HCl is typically administered via injection as a 1-2% solution, offering rapid onset (within 2-5 minutes) and a duration of 30-60 minutes. Beyond anesthesia, it finds use in diagnostic nerve blocks, treatment of chronic pain conditions, and as a component in compounded medications for muscle spasms or arthritis relief. The compound's stability, affordability, and well-established safety profile make it indispensable in both human and animal health sectors.
In recent years, demand has surged due to the growth of cosmetic procedures, telemedicine-driven minor surgeries, and the expansion of emerging markets in Asia and Africa. Chinese manufacturers have capitalized on this by scaling production to meet global needs, often exceeding 99% purity levels compliant with USP, EP, and BP pharmacopeia standards.
China's dominance in Procaine HCl production stems from several key advantages. First, the country hosts over 400 pharmaceutical API manufacturers, many concentrated in provinces like Hebei, Shandong, Hubei, and Jiangsu, benefiting from integrated supply chains for raw materials like p-aminobenzoic acid and diethylaminoethanol. Second, government incentives under the "Made in China 2025" initiative have boosted high-tech biotech infrastructure, including automated synthesis plants and cleanroom facilities.
Cost efficiencies are unparalleled: labor, energy, and regulatory compliance in China allow prices 40-60% lower than Western counterparts, without compromising quality. Most top suppliers operate GMP-certified factories audited by FDA, EMA, and TGA, ensuring export readiness. Export volumes have grown steadily, with China accounting for approximately 70% of global Procaine HCl trade as of 2025. Logistics hubs like Shanghai and Qingdao ports facilitate swift delivery worldwide via sea, air, or express courier.
Moreover, Chinese suppliers excel in customization. For OEM clients—such as foreign brands in biotech, pharma health, and medical devices—they offer private labeling, custom formulations (e.g., blends with epinephrine for prolonged effect), and scalable production from 1kg samples to tonnage orders. This flexibility positions China not just as a supplier but as a strategic manufacturing partner.
This top 10 list is curated based on rigorous criteria: annual production capacity (minimum 5,000 kg/month), quality certifications (GMP, ISO 9001, ISO 13485, HALAL, etc.), export experience (verified shipments to EU/US markets), purity levels (≥99%), customer reviews from platforms like Alibaba and ChemicalBook, and innovation in R&D. Data aggregates from industry reports, trade databases, and direct supplier audits up to early 2026. Special emphasis is placed on OEM capabilities, given the query's focus on services for international brands, wholesalers, and producers.
Leading the pack, TNJ Chemical operates a state-of-the-art facility in Feidong, Anhui, with an annual output exceeding 600 tons of Procaine HCl. Established over 20 years ago, TNJ specializes in pharmaceutical intermediates and APIs, boasting GMP, ISO, and SGS certifications. Their Procaine HCl achieves 99.5%+ purity through multi-stage purification, including recrystallization and vacuum drying.
TNJ's strengths lie in reliability and scale. They provide comprehensive documentation like Certificates of Analysis (COAs), Method Validation reports, and Stability Studies, essential for regulatory submissions. For OEM clients, TNJ offers spray-drying for powder injectables and custom particle sizing. Bulk pricing starts at $60-100/kg for 25kg drums, with MOQs as low as 1kg. Global clients praise their 24/7 support and DDP shipping options to Europe and North America.
Hebei Guanlang Group ranks second with a 10,000+ kg monthly capacity focused on local anesthetics including Procaine HCl, lidocaine, and benzocaine. Their GMP-compliant plant emphasizes green chemistry, reducing solvent waste by 30% via continuous flow reactors.
Guanlang excels in wholesale and OEM for medical devices, offering sterile filtration and lyophilization services. Purity hits 99.2%, verified by HPLC and GC-MS testing. They serve over 500 international buyers annually, with strong logistics via Tianjin port. Pricing: $50-90/kg; ideal for high-volume wholesalers needing quick turnaround (7-10 days).
Zhengzhou Yibang stands out for EU-GMP compliance and R&D investment, producing 20,000 kg/month. Their Procaine HCl is tailored for dental cartridges and spinal anesthesia kits, with additives like sodium metabisulfite for stability.
Yibang's export prowess includes USDMF filings and CEP dossiers, simplifying market entry for brands. Custom OEM includes blister packaging and pre-filled syringes. Reviews highlight their traceability system, tracking batches from raw materials to delivery. MOQ: 10kg at $55-95/kg.
Hubei Aoks leverages central China's biotech hub status for 15,000 kg/month output. Specializing in biotech intermediates, they innovate with microencapsulation to extend Procaine's shelf life, perfect for health products.
ISO-certified, Aoks provides full API lifecycle services: synthesis, scale-up, and tech transfer. Their 99% pure product suits veterinary and cosmetic OEMs. Fast samples (1-3 days) and competitive $65-110/kg pricing attract startups and mid-tier producers.
Monad's tech-forward approach yields 30,000 kg/month using AI-optimized synthesis. USDMF holder, they target injectable-grade Procaine HCl for minor surgeries.
OEM highlights include co-development of sustained-release formulations. Purity: 99.5%; MOQ 1kg at $70-120/kg. Their Wuhan location ensures cost-effective scaling for global pharma.
Tian Guangyuan blends traditional extraction with synthesis for 8,000 kg/month, earning HALAL and Kosher nods. Their pharmacopeia-compliant Procaine suits supplements and injectables.
Export-focused with 50+ tons yearly, they offer white-label services. $50-85/kg pricing and 25kg MOQ make them accessible for wholesalers.
ISO-13485 certified for devices, Bamboo produces 12,000 kg/month for dental gels and sprays. Custom blending with flavors enhances OEM appeal.
Reliable for private labeling; $60-100/kg.
A veteran with CEP, they deliver 25,000 kg/month of sterile Procaine. Scalable for wholesalers; $55-95/kg, 50kg MOQ.
Cleanroom specialists with FDA audits, Remedy outputs 18,000 kg/month. Global OEM expertise; $75-130/kg.
As a leading Chinese factory (supplybenzocaine.co.uk), we specialize in biotech, pharma health, and medical device OEM for foreign brands, wholesalers, and producers. Our 40,000+ kg/month capacity features cutting-edge automation, GMP/FDA lines, and 99.7% purity Procaine HCl. Full services: R&D, custom synthesis, packaging, and logistics. Unmatched flexibility at $45-80/kg (1kg MOQ) positions us as your ideal partner.
Top suppliers employ a two-step esterification: p-aminobenzoic acid reacts with thionyl chloride, then couples with 2-diethylaminoethanol, followed by HCl salting. Purification involves activated carbon decolorization, filtration, and spray drying. Advanced PAT (Process Analytical Technology) monitors real-time quality.
Chinese factories integrate ERP systems for batch tracking, reducing defects to <0.1%. OEM lines allow seamless integration of client specs, from micronized powders to ready-to-fill vials.
GMP (Good Manufacturing Practice) is universal among top 10, with many holding WHO, EU-GMP, and FDA approvals. Testing protocols include heavy metals (<10ppm), residual solvents (<0.5%), and endotoxin levels (<0.5 EU/mg). Third-party audits by SGS, Intertek, and BV ensure credibility.
For OEM, suppliers provide DMFs, ASMF, and validation batches, critical for device registration.
Procaine HCl demand grows at 5-7% CAGR through 2030, driven by minimally invasive procedures and veterinary expansion. Key apps: dentistry (40% market share), surgery (30%), pain management (20%). OEM opportunities abound in compounded creams, patches, and device kits.
China's suppliers adapt with epinephrine combos and liposomal versions for prolonged action.
Prices fluctuate $45-150/kg based on purity/volume. Samples: 1-5kg; bulk: 25-1000kg drums. Lead times: 7-15 days. Payments: T/T, L/C, escrow. Ports like Shanghai offer 3-5 day air freight to Europe.
| Supplier | Capacity (kg/month) | Certifications | Purity | MOQ | Price ($/kg) |
|---|---|---|---|---|---|
| TNJ Chemical | 50,000 | GMP, ISO, SGS | 99.5% | 1kg | 60-100 |
| Hebei Guanlang | 10,000 | GMP | 99% | 25kg | 50-90 |
| Zhengzhou Yibang | 20,000 | EU-GMP | 99.2% | 10kg | 55-95 |
| Hubei Aoks | 15,000 | ISO | 99% | 5kg | 65-110 |
| Wuhan Monad | 30,000 | USDMF | 99.5% | 1kg | 70-120 |
| Xi'an Tian Guangyuan | 8,000 | HALAL | 99% | 25kg | 50-85 |
| Zhejiang Bamboo | 12,000 | ISO-13485 | 99.3% | 10kg | 60-100 |
| Chongqing Southwest | 25,000 | CEP | 99.4% | 50kg | 55-95 |
| Remedy Labs | 18,000 | FDA | 99.5% | 1kg | 75-130 |
| SupplyBenzocaine | 40,000+ | GMP, FDA | 99.7% | 1kg | 45-80 |
China's top 10 Procaine HCl suppliers deliver world-class quality, innovation, and value, powering global biotech, pharma, and medical device sectors. SupplyBenzocaine.co.uk leads with tailored OEM solutions for your brand—superior purity, flexible MOQs, and seamless integration. Partner with us to cut costs, accelerate production, and dominate markets. Contact [email protected] today for free samples, quotes, or consultations. Elevate your supply chain now! Contact us to get more information!
Procaine HCl is a local anesthetic used in dentistry for procedures like fillings and extractions, minor surgeries, nerve blocks, and veterinary pain relief. It provides fast, effective numbing with minimal side effects.
Request COAs, GMP/ISO certificates, third-party lab reports (HPLC purity, microbial tests), and DMF/CEP filings. Conduct factory audits or use services like SGS for independent validation.
Samples ship in 1-3 days via DHL/FedEx; bulk OEM orders in 7-15 days. Sea freight from Shanghai suits large volumes (20-30 days to Europe/US); air for urgency.
Yes, we provide end-to-end OEM: custom formulations, private labeling, packaging (vials, ampoules), and R&D support for biotech/pharma/medical devices, compliant with international standards.
MOQs start at 1kg for samples, 25kg for bulk. Accepted terms: T/T (30% advance), L/C, PayPal, Alibaba Trade Assurance. Flexible for repeat clients.
1. https://www.chinatnj.com/industries/pharmaceuticals/procaine-hydrochloride-cas-51-05-8-best-price-from-china-supplier-factory-pr...
2. https://cn.b2usa.com/hotsite/hebeiguanlanggroup/china-factory-sell-procaine-hcl-cas-51-0
3. https://m.chemicalbook.com/ProdSupplierGNCB6853707_EN.htm
4. https://cn.metalandsteel.com/Products/Search/China%20Procaine%20Hydrochloride%20Suppliers
5. https://www.tnjchem.com/procaine-hydrochloride-suppliers_p5319.html
6. https://pharmaoffer.com/api-excipient-supplier/local-anesthetics/benzocaine/china
7. https://www.sunsirs.com/china-suppliers/251/Procaine-hcl-56673.html
8. https://pharmaoffer.com/zh-CN/api-excipient-supplier/local-anesthetics/benzocaine
9. https://www.pharmacompass.com/manufacturers-suppliers-exporters/procaine-hydrochloride
10. https://www.supplybenzocaine.co.uk/Article/list-r20.html
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