Content Menu
● Overview of Benzocaine Supply Market
● Key Quality Standards and Certifications
● Leading Benzocaine Suppliers
>> Shaanxi Bieyouth Biotech Co., Ltd.
● Production Process of Pharmaceutical-Grade Benzocaine
● Pricing Comparison for 25kg Benzocaine
● Logistics, Packaging and Supply Chain Considerations
● Applications and Industry Uses of Benzocaine
● Frequently Asked Questions (FAQs)
>> 1. What purity level should I expect in pharmaceutical benzocaine?
>> 2. How is benzocaine usually packaged for international shipping?
>> 3. What certifications are essential when choosing a benzocaine supplier?
>> 4. What factors influence benzocaine pricing in 25kg quantities?
>> 5. Can suppliers provide benzocaine samples for quality verification?
Benzocaine is a widely used local anesthetic and topical pain reliever commonly supplied in bulk quantities such as 25kg bags or drums. Leading suppliers provide pharmaceutical-grade benzocaine with purity typically ≥99% to meet international standards. This comprehensive article compares top benzocaine suppliers, focusing on quality credentials, pricing, production capabilities, certifications, and logistical reliability. It aims to assist overseas brands, wholesalers, and manufacturers sourcing OEM benzocaine from China and other key global hubs.
China dominates the benzocaine powder manufacturing sector with key production centers in Shaanxi, Jiangsu, and Zhejiang provinces. These industrial clusters integrate raw material sourcing, advanced synthesis, quality control, and export logistics, delivering competitive prices and consistent product quality. Many suppliers hold GMP, ISO, and DMF certifications, ensuring pharmaceutical-grade production suitable for international markets including Europe and the UK.
- GMP (Good Manufacturing Practice) certification ensuring high hygienic and production standards
- ISO 9001 or equivalent quality management
- Compliance with pharmacopoeia grades: USP, BP, EP, IP
- COA (Certificate of Analysis) verifying ≥99% purity, batch consistency, and contaminant-free product
- Third-party lab testing for residual solvents, heavy metals, and other impurities
- Review score 4.8/5, response time ≤2h, 99.3% on-time delivery
- Estimated annual revenue US $290,000+, reorder rate 28%
- Production facilities covering 130+ m² with 20+ staff
- Known for reliable pharmaceutical-grade benzocaine and prompt customer service
- Over 15 years in benzocaine production and export
- Offers industrial and pharmaceutical grade benzocaine (20-40 mesh; 50 & 200 mesh)
- GMP, DMF and EGMP certified, supplying Western markets including UK
- Products supplied in 25kg double poly bags within HDPE drums
- Known for consistent high purity and advanced manufacturing technology
- Manufacturer of benzocaine API meeting IP/BP/USP/EP standards
- Exports globally with compliance to DCGI, WHO-GMP, FDA regulations
- Packs benzocaine in 25kg double poly bags, with a wide pharmaceutical market footprint
- Pharm-RX Chemical Corporation (USA) — Distributor and custom manufacturer for pharmaceutical industries
- Spectrum Chemical Mfg. Corp. (USA) — Large scale API manufacturer with ISO 9001 certification
- Changzhou Sunlight Pharmaceutical (China) — Manufacturer of APIs including benzocaine with EU regulatory compliance
The production of benzocaine involves a multi-step chemical synthesis aimed at delivering high purity and consistent quality. A widely adopted industrial method includes the esterification of p-nitrobenzoic acid with ethanol under reflux conditions in the presence of a strong mineral acid catalyst to produce ethyl p-nitrobenzoate. This intermediate undergoes careful washing to remove catalyst residues, excess alcohol, and unreacted acids while still in solution, shortening purification time significantly compared to older batch processing methods.
Subsequently, the purified intermediate is catalytically reduced, commonly via hydrogenation with a palladium-carbon catalyst, converting ethyl p-nitrobenzoate to benzocaine (ethyl p-aminobenzoate). After reduction, the product is treated with adsorbents such as metallic oxides to remove impurities. Benzocaine crystallizes upon cooling to room temperature, providing a final product of high purity, typically exceeding 99%. The entire process can be completed within approximately 13 hours, including esterification and reduction steps, with yields around 84% of theoretical calculations. This streamlined method offers consistent batch-to-batch quality and minimizes time-consuming isolation steps traditionally associated with benzocaine production.
Pricing varies based on purity grade, batch size, and certification. Approximate price ranges per kg among top suppliers are as follows:
- Shaanxi Bieyouth Biotech: Competitive pricing reflecting premium GMP quality (~$10-15/kg)
- TNJ Chemical: Factory direct prices, dependent on grade and mesh size (~$8-14/kg)
- Indian Manufacturers (Cerata Pharma): Typically $9-16/kg based on grade and regional logistics
- US-based suppliers: Higher tier pricing consistent with quality certifications and service (~$15-25+/kg)
Additional factors affecting cost include shipping fees, import duties, bulk order discounts, and custom packaging options. Negotiating pricing based on volume and long-term partnership potential is common in the industry.
- Common packaging: 25kg per bag or drum, usually double poly bags inside HDPE drums to maintain product integrity
- Reliable suppliers provide export documentation, COA, and batch traceability documentation
- On-time delivery rates for leading suppliers exceed 98%, with responsiveness under two hours reported
- Virtual factory tours or audits by clients are often accommodated to build trust and verify capabilities
- Shipping options include sea freight, air freight, or express courier services, depending on urgency and destination
Benzocaine's primary application is as a local anesthetic in pharmaceutical and healthcare products, including topical creams, gels, sprays, and oral care products. It is also used in medical devices such as throat lozenges, cough drops, and local anesthetic sprays for minor surgeries and dental procedures. OEM manufacturers rely on high-quality benzocaine as a key active pharmaceutical ingredient (API) for formulation of over-the-counter (OTC) and prescription drugs globally.
(Note: For a rich user experience, it is recommended to include images and videos showing benzocaine powder, manufacturing facilities, quality control labs, and packaging procedures, but these are not embedded here.)
Choosing the right 25kg benzocaine supplier demands attention to quality certifications, price competitiveness, logistical reliability, and proven OEM experience. Suppliers such as Shaanxi Bieyouth Biotech, TNJ Chemical, and Cerata Pharma exemplify high standards and global compliance for pharmaceutical-grade benzocaine. Brands and manufacturers should request COAs, consider production capacity, and validate supplier credentials to ensure superior product quality and timely delivery.
Call to Action:
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Pharmaceutical-grade benzocaine typically has a purity of ≥99%, confirmed via certificates of analysis and independent lab tests to meet pharmacopoeial standards such as USP, BP, and EP.
Benzocaine is commonly packed in 25kg double poly bags within HDPE drums to protect the powder from moisture and contamination during shipping and storage.
Look for GMP, ISO 9001, DMF, WHO-GMP certifications to ensure quality manufacturing, along with batch-specific COAs demonstrating purity and safety compliance.
Pricing is influenced by purity grade, supplier location, order volume, certification costs, packaging, and shipping logistics. Bulk order discounts and long-term contracts often reduce cost.
Most verified suppliers offer samples for quality testing, though the availability of free or paid samples depends on the supplier's policy and buyer qualification.
[1](https://patents.google.com/patent/US3037046A/en)
[2](https://www.slideshare.net/slideshow/synthesis-of-benzocaine/247994205)
[3](https://patents.google.com/patent/CN112516074A/en)
[4](https://www.athabascau.ca/science-and-technology/_documents/centre-for-science-files/labs/organic-chemistry/exp/17_benzocaine.pdf)
[5](https://www.cliffsnotes.com/study-notes/17041700)
[6](https://www.youtube.com/watch?v=RiTN1EYB-rs)
[7](https://pmc.ncbi.nlm.nih.gov/articles/PMC9321682/)
[8](https://www.sciencedirect.com/topics/chemistry/benzocaine)
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