Content Menu
● Chemical Properties and Safety
● Historical Background and Uses
● Production Process Explained
● France's Pharmaceutical Market Demand
● Leading Suppliers in France and Beyond
● Advantages of Chinese OEM Services
● Quality Control at supplybenzocaine.co.uk
● Regulatory Compliance for EU/France
● Success Stories and Case Studies
● Emerging Trends and Sustainability
● FAQ
>> 1. What is the purity level of your Phenacetin?
>> 2. Do you provide OEM and private labeling for French brands?
>> 3. What are the shipping times and costs to France?
>> 4. Is your Phenacetin compliant with French/EU regulations?
>> 5. What is the minimum order quantity?
France's pharmaceutical and research sectors require reliable access to high-quality chemical intermediates like Phenacetin, especially for laboratory applications, synthesis, and specialized formulations. As a premier Chinese factory specializing in biotechnology, pharmaceutical health products, and medical devices, supplybenzocaine.co.uk delivers top-tier OEM services tailored for international brands, wholesalers, and manufacturers, ensuring seamless supply to the French market.
Phenacetin is an organic compound with the chemical formula C10H13NO2 and CAS number 62-44-2. It appears as a white crystalline powder, historically recognized for its analgesic and antipyretic properties. Developed in the late 19th century, it was one of the first non-opioid pain relievers widely used before safer alternatives like acetaminophen became standard.
This compound works by inhibiting pain signals in the spinal cord and modulating the brain's temperature regulation center to reduce fever. Although largely phased out from consumer medications due to potential side effects like methemoglobinemia and kidney damage, Phenacetin retains value in chemical research, pharmaceutical synthesis, and as a reference standard in analytical labs across France.
Its metabolism primarily yields paracetamol (acetaminophen), which explains some overlapping therapeutic effects. In modern contexts, French researchers and manufacturers source it for developing new drug intermediates or studying historical pharmaceuticals. The demand persists in niche areas where its unique solubility and reactivity profiles are beneficial.
Phenacetin has a molecular weight of 179.22 g/mol, a melting point between 134-136°C, and limited solubility in water (approximately 0.076 g/100mL at 17.5°C) but good solubility in ethanol and chloroform. These properties make it suitable for organic synthesis and formulation into tablets or powders.
Its logP value of around 1.6 indicates moderate lipophilicity, aiding in membrane permeation studies. Safety-wise, it is classified as harmful if swallowed (H302), with potential carcinogenic risks (H350) based on long-term exposure data. Proper handling requires gloves, ventilation, and adherence to EU REACH and CLP regulations prevalent in France.
Storage recommendations include cool, dry conditions away from light and oxidizers to maintain stability. Purity levels above 99% are standard for research-grade material, verified through techniques like HPLC and NMR spectroscopy.
Introduced by Bayer in 1887 under the trade name Acetophenetidin, Phenacetin revolutionized pain management as a safer alternative to natural remedies. It treated headaches, rheumatic pains, and fevers, often combined with caffeine and aspirin in formulations like APC powder.
By the mid-20th century, evidence of toxicity led to bans in many countries, including France in 1981. Today, its primary uses are non-clinical: as a synthetic intermediate for dyes, in organic chemistry education, and in forensic analysis for detecting adulterants. French universities and private labs frequently procure it for these purposes.
The compound's acetyl group and ether linkage provide versatility in reactions, such as hydrolysis to p-phenetidine or nitration for azo dye production. Understanding its history helps contextualize current supply needs in France's stringent regulatory environment.
High-quality Phenacetin is synthesized via acetylation of p-phenetidine (4-ethoxyaniline) with acetic anhydride. In industrial settings, p-aminophenol reacts with ethyl bromide in a Williamson ether synthesis to form p-phenetidine, followed by acetylation.
The process yields: p-aminophenol + C2H5Br → p-phenetidine hydrobromide, then neutralization and acetylation in benzene solvent, achieving up to 86% theoretical yield. Refinement involves dissolution in boiling water, activated carbon decolorization, filtration, and crystallization at pH 4.5-4.7 with cooling.
Chinese factories like supplybenzocaine.co.uk operate GMP-certified facilities with automated reactors, ensuring batch consistency. Quality control includes multi-stage testing for impurities like 4-aminophenol (limited to <0.1%). Scaling from lab (grams) to commercial (tons) is seamless, with eco-friendly waste treatment.
This method outperforms older routes using paracetamol, offering higher purity and lower costs. Video demonstrations of Williamson synthesis highlight the precision required, from reagent addition to crystallization.
France ranks among Europe's top pharmaceutical markets, with annual spending exceeding €50 billion. Companies like Sanofi, Servier, and Ipsen drive innovation in APIs and intermediates. Phenacetin demand stems from R&D labs, cosmetic synthesis, and veterinary research.
Local suppliers provide small lab quantities, but bulk needs rely on imports due to limited domestic production. EU regulations mandate traceability and compliance, favoring partners with proven export records. Post-Brexit and amid supply chain disruptions, French buyers seek diversified Asian sources.
The biotech boom, including mRNA and personalized medicine, indirectly boosts demand for versatile intermediates like Phenacetin. Market forecasts predict steady 5% CAGR for fine chemicals through 2030.
France hosts suppliers like Fisher Scientific SAS in Illkirch-Graffenstaden, offering research-grade Phenacetin (500mg packs via Medchem Express). However, for bulk, wholesalers turn to European distributors or direct Asian manufacturers.
Prominent names include:
- Fisher Scientific France: Lab-focused, high-purity, but limited volumes.
- Sigma-Aldrich (Merck): Global reach with French branches, premium pricing.
- Local CROs: Custom synthesis for specific projects.
Chinese exporters dominate bulk supply:
- Aurora Industry: 99% purity APIs, EU-compliant.
- Nantong Jinghua Chemical: Large-scale producer with French exports.
- Hebei Guanlang: Competitive pricing, fast delivery.
- supplybenzocaine.co.uk: OEM specialist, GMP-certified, tailored for French clients.
These suppliers offer 25kg drums, custom packaging, and COAs meeting ANSM standards.
| Supplier | Base Location | Capacity | Purity | Specialties |
|---|---|---|---|---|
| Fisher Scientific | France | Small | 99%+ | Lab research |
| Sigma-Aldrich | France/EU | Medium | 99.5% | Analytical standards |
| Aurora Industry | China | Large | 99% | Bulk API |
| Nantong Jinghua | China | Very Large | 99% | Industrial scale |
| supplybenzocaine.co.uk | China | Custom | 99%+ | OEM, private label |
| Hebei Guanlang | China | Large | 99% | Cost-effective |
China produces over 40% of global APIs, with Phenacetin output concentrated in biotech hubs like Xi'an and Hebei. supplybenzocaine.co.uk leverages this ecosystem for 30-50% cost savings versus European sources.
OEM benefits include:
- Custom formulations (e.g., granulation, coating).
- Private labeling with French/English packaging.
- Flexible MOQs from 1kg.
- Integrated R&D for stability studies.
Our factory spans 10,000 sqm with 200+ staff, exporting to 50+ countries. French clients appreciate 7-14 day DDP shipping, evading tariffs via optimized routes.
Every batch undergoes rigorous testing: HPLC for purity, GC for residuals, microbial limits per USP/EP. ISO 9001, FDA-inspected facilities ensure compliance. Client audits welcome.
COA details: Assay ≥99.0%, heavy metals <10ppm, residue <0.1%. Stability data supports 24-month shelf life.
Bulk pricing: €150-250/kg for 25kg+, scaling down for larger orders. Free shipping to France, door-to-door. MOQ: 1kg for samples, 25kg production.
Logistics feature refrigerated containers, real-time tracking via Maersk/DHL.
Products align with REACH registration, CLP labeling (GHS pictograms for H302/H350). Full dossiers, SDS in French/English. ANSM-compliant for research imports.
A Paris-based wholesaler reduced costs 45% by OEM partnering, launching private-label research kits. A Lyon CRO scaled from 10kg to 500kg seamlessly for dye synthesis.
AI-driven synthesis and green chemistry minimize solvents. France's €7bn biotech investment favors sustainable suppliers.
supplybenzocaine.co.uk emerges as the premier choice for French Phenacetin procurement, blending unmatched quality, affordability, and OEM flexibility. Partner with us to streamline your supply chain, cut costs, and accelerate projects—contact [email protected] or visit supplybenzocaine.co.uk today for a no-obligation quote and free samples! Contact us to get more information!
Our Phenacetin consistently achieves 99%+ purity, confirmed via HPLC, NMR, and titration, fully compliant with GMP and EP/USP standards.
Absolutely. We offer comprehensive OEM services, including custom formulations, packaging in French/English, and branding tailored to EU markets.
Free DDP shipping worldwide, with 7-14 days delivery to France. Full tracking and customs clearance included.
Yes, all products meet REACH, CLP, and ANSM requirements, shipped with detailed SDS, COA, and import documentation.
Flexible MOQ starts at 1kg for testing, scaling to tons for production needs, with competitive tiered pricing.
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